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Bioplanet generif analysis
NFKB1 transcription factor network and disease associations. (A) Lisa analysis identifying transcription factors associated with the expression LPS dependent of genes differentially expressed in NFKB1 -/- cells (p < 0.01). Top most significant factors indicated by orange symbols. (B) Identification of disease associated gene signatures in the <t>GeneRif</t> database with significant similarity to the transcriptional signature of LPS-stimulated NFKB1 -/- cells (q value < 0.05). Heatmap on right shows selected genes associated with the severe combined and common variable immunodeficiency disease signatures, Z-score normalized.
Generif Analysis, supplied by Bioplanet, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/generif+analysis/pmc08548695-168-3-1?v=Bioplanet
Average 90 stars, based on 1 article reviews
generif analysis - by Bioz Stars, 2026-07
90/100 stars

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1) Product Images from "Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells"

Article Title: Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells

Journal: Frontiers in Immunology

doi: 10.3389/fimmu.2021.669906

NFKB1 transcription factor network and disease associations. (A) Lisa analysis identifying transcription factors associated with the expression LPS dependent of genes differentially expressed in NFKB1 -/- cells (p < 0.01). Top most significant factors indicated by orange symbols. (B) Identification of disease associated gene signatures in the GeneRif database with significant similarity to the transcriptional signature of LPS-stimulated NFKB1 -/- cells (q value < 0.05). Heatmap on right shows selected genes associated with the severe combined and common variable immunodeficiency disease signatures, Z-score normalized.
Figure Legend Snippet: NFKB1 transcription factor network and disease associations. (A) Lisa analysis identifying transcription factors associated with the expression LPS dependent of genes differentially expressed in NFKB1 -/- cells (p < 0.01). Top most significant factors indicated by orange symbols. (B) Identification of disease associated gene signatures in the GeneRif database with significant similarity to the transcriptional signature of LPS-stimulated NFKB1 -/- cells (q value < 0.05). Heatmap on right shows selected genes associated with the severe combined and common variable immunodeficiency disease signatures, Z-score normalized.

Techniques Used: Expressing



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Bioplanet generif analysis
NFKB1 transcription factor network and disease associations. (A) Lisa analysis identifying transcription factors associated with the expression LPS dependent of genes differentially expressed in NFKB1 -/- cells (p < 0.01). Top most significant factors indicated by orange symbols. (B) Identification of disease associated gene signatures in the <t>GeneRif</t> database with significant similarity to the transcriptional signature of LPS-stimulated NFKB1 -/- cells (q value < 0.05). Heatmap on right shows selected genes associated with the severe combined and common variable immunodeficiency disease signatures, Z-score normalized.
Generif Analysis, supplied by Bioplanet, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/generif+analysis/pmc08548695-168-3-1?v=Bioplanet
Average 90 stars, based on 1 article reviews
generif analysis - by Bioz Stars, 2026-07
90/100 stars
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NFKB1 transcription factor network and disease associations. (A) Lisa analysis identifying transcription factors associated with the expression LPS dependent of genes differentially expressed in NFKB1 -/- cells (p < 0.01). Top most significant factors indicated by orange symbols. (B) Identification of disease associated gene signatures in the GeneRif database with significant similarity to the transcriptional signature of LPS-stimulated NFKB1 -/- cells (q value < 0.05). Heatmap on right shows selected genes associated with the severe combined and common variable immunodeficiency disease signatures, Z-score normalized.

Journal: Frontiers in Immunology

Article Title: Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells

doi: 10.3389/fimmu.2021.669906

Figure Lengend Snippet: NFKB1 transcription factor network and disease associations. (A) Lisa analysis identifying transcription factors associated with the expression LPS dependent of genes differentially expressed in NFKB1 -/- cells (p < 0.01). Top most significant factors indicated by orange symbols. (B) Identification of disease associated gene signatures in the GeneRif database with significant similarity to the transcriptional signature of LPS-stimulated NFKB1 -/- cells (q value < 0.05). Heatmap on right shows selected genes associated with the severe combined and common variable immunodeficiency disease signatures, Z-score normalized.

Article Snippet: For BioPlanet and GeneRif analysis upregulated, and downregulated genes were used as one list to provide a broader view.

Techniques: Expressing